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Prescribing Information for Provera (Medroxyprogesterone):
What is Provera (Medroxyprogesterone)?
Provera is a drug mainly used for the disorders of menstrual cycle in women. It contains medroxyprogestrone acetate as a main ingredient of the drug. Pharmacia holds the brand Provera. Provera contains artificial or synthetic form of naturally occurring female hormone progesterone.
What should I know about Provera (Medroxyprogesterone)?
It can treat various disorders of menstrual cycle in women. Menstrual cycle is naturally occurring cycle in women which is marked by proliferative, growth and menstrual phases. It is a complex process regulated by hormones at different phases during the cycle. The hormones may decline or rise during different phases of the cycle. Progesterone can increase in the proliferative phase of the menstrual cycle.
The increased amount of hormone proliferates the living of womb for the imbedding of the fertilized egg if union of ova and sperm takes place. If fertilization does not occur, shedding of womb living which includes bleeding from uterus. This is the menstrual period.
There are numerous factors in menstrual period which can produce disorders in women. If menstrual hormones are not synthesized in adequate these can cause various changes in menstruation.
Medroxyprogestrone can help women to restore their natural hormone levels. It will mimic the function of naturally occurring hormone progesterone in the body. The levels of progesterone increase in blood many weeks before the occurrence of menstrual phase. If Provera is taken for 5 to 10 days very menstrual cycle it will increase progesterone levels naturally.
This will help menstrual cycle to go in a normal way. When you will stop taking your tablets, menstruation will be seen at the end of ingestion of Provera. This can be done every menstrual cycle soon you will observe that your natural menstrual cycle is returning and you don’t need any more pills of medroxyprogesterone.
Provera tablets or medroxyprogestrone tablets can also be used for the treatment of endometriosis. Endometriosis is a condition in which the womb living grows over the ovaries, womb and bladder in an uncontrolled manner. Provera tablets when consumed thrice a day will increase your progesterone levels and as you stop Provera tablets suddenly will lead to menstruation in women.
After a regular or a constant treatment with Provera (Medroxyprogesterone) the endometrial tissue in endometriosis will shrink altogether. Provera is mainly used for the treatment of milk to moderate endometriosis, amenorrhea or complete absence of menses. It can also treat DVB or dysfunctional uttering bleeding. It can also treat very frequent periods. It is highly contraindicated in pregnancy. It has not been proved in pregnant women. It can produce bleeding which is very fatal sign in pregnant women.
This can prove to be harmful in lactating mothers as it can pass through mother’s milk. Do not take Provera if you are planning to get pregnant side effects like stabbing pain, difficult breathing, hematemesis or blood on coughing, breathlessness, epilepsy severe disturbance can occur after taking this drug.
If you feel any severe reaction, consult your doctor immediately. Patients suffering from decreased kidney and low liver function should use it carefully. You must prescribe it continuously if a person had suffered asthma attack, hypertension, and diabetes before taking this drug. Those who have history of depression should also use it carefully.
Do not use Provera (Medroxyprogesterone) in moderate to severe liver disease, breast cancer, pregnancy, heart attack, lactating mothers and persons with rare hereditary blood disease known as porphyrias and patients of heart having angina. Those who had any allergic reactions by use of artificial hormone should not take this drug. This can pass through placenta and mother milk hence, it can harm the gestating and breastfeeding mothers consult your doctor to conceive or you should not feed your newborn while taking Provera.
How to use Provera (Medroxyprogesterone)?
Provera must be used exactly as prescribed by your doctor or as per the instructions on the prescription table. Do not overdose or miss any dose of Provera as it will cause changes in your menstrual cycle. Take the drug carefully, if you miss any dosage, do not take extra drug of Provera. Take Provera (Medroxyprogesterone) with one full glass of water and don’t combine it with alcohol or any other liquid.
What are the side effects of Provera (Medroxyprogesterone)?
Provera can cause rare to milk side effects occurring in individual patients depending upon their susceptibility and other factors. It can produce tenderness of breast, fluid retention, weight gain, nervousness, dizziness, nausea, indigestion, bloating, depression, insomnia or difficulty in sleeping, skin rashes, acne, alopecia, increased growth of hair i.e. hirsutism etc. Possible risks may be associated with this drug. Go through prescription label carefully and consult your doctor if any severe side effects occur. Don’t over dose under any circumstances.
How Provera (Medroxyprogesterone) interacts with other drugs?
You doctor will ask you all the herbal supplements and over the counter (OTC) drugs that you have been taking. You must tell every supplement that you think is unimportant before starting Provera (Medroxyprogesterone).
These drugs can make Provera (Medroxyprogesterone) less effective-barbiturates, nelfinavir, rifonavir, rifampicin, antiepileptic drugs like carbamazepine, phenytoin etc. It will also become less effective with hypericum perforatum. The blood levels of Provera decreases when combined with anti epileptic medicines like lamotrizine.