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Prescribing Information for Estrace (Estradiol):
What is Estrace?
Estrace (estradiol) is an estrogen (female sex hormone produced by the ovaries) substitute. It is important for lots of processes in the human organism.
Estrace is prescribed for treatment of menopause symptoms like hot flashes, and vaginal dryness, burning, and irritation. It can also be used to prevent osteoporosis in women after menopause, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.
Estrace may also be prescribed for other uses.
What is important to know about Estrace?
Estrace can be harmful for unborn baby or it can provoke birth defects. You should avoid using Estrace if you are pregnant, if you have unusual vaginal bleeding, liver problems, breast or uterine cancer, hormone-dependent cancer, if you have recently had heart attack or stroke, if you have a history of blood clot (especially in your lung or your lower body), or if you have allergy to any medicines or food dyes. When you are using hormones, your risk of blood clots, stroke, or heart attack can enlarge especially if you suffer from high high cholesterol or triglycerides, blood pressure, diabetes, if you are overweight, or if you smoke.
Your risks of breast cancer, ovarian cancer, or uterine cancer can enlarge if you use Estrace for a long time. Ask your doctor about your personal risks before you start using Estrace long-term. Your doctor will need to examine you every 3 to 6 months to check if your condition improves and if you should continue using this medication.
If your ulterus has not been removed, your doctor may tell you to combine Estrace with progestin to make your risk of uterine cancer lower.
Do not use Estrace in order to prevent dementia, heart disease or stroke because the medicine can increase the risk of these diseases.
You should visit your doctor regularly to be examined and to have mammograms, and you should examine your breasts for lumps yourself every month during all the period of treatment with Estrace.
How should Estrace be used?
Follow the prescriptions of your doctor carefully. Do not change your dose and do not use Estrace for a longer period than prescribed.
Your risks of breast cancer, ovarian cancer, or uterine cancer can enlarge if you use Estrace for a long time. Ask your doctor about your personal risks before you start using Estrace long-term.
If your ulterus has not been removed, your doctor may recommend you to combine Estrace with progestin to make your risk of uterine cancer lower.
You should visit your doctor regularly to be examined and to have mammograms, and you should examine your breasts for lumps yourself every month during all the period of treatment with Estrace. Your doctor will need to examine you every 3 to 6 months to check if your condition improves and if you should continue using this medication.
If you are going to have any type of surgery, or to stay on bed rest, it may be necessary to stop taking Estrace for some period of time.
Keep the medicine at room temperature protected from heat, light, and moisture.
What side effects can Estrace cause?Seek emergency medical attention if you experience any of the following symptoms of allergy: trouble breathing; hives; swelling of your face, lips, tongue, or throat. You should stop using Estrace and call your doctor promptly if you develop any of the following serious conditions:
- a lump in your breast;
- stabbing chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- jaundice (yellowing of the skin or eyes);
- sudden severe headache, confusion, problems with vision, speech, or balance;
- pain, swelling, or tenderness in your stomach;
- nausea, vomiting, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless;
- uncommon vaginal bleeding (especially if you are past menopause);
- pain, swelling, warmth, or redness in one or both legs;
- unexpected numbness or weakness, especially on one side of the body; or
- feeling like you might pass out.
- loss of scalp hair;
- vaginal itching or discharge;
- freckles or darkening of facial skin;
- breast pain, tenderness, or swelling;
- changes in your menstrual periods, break-through bleeding; or
- mild nausea, vomiting, bloating, stomach cramps.
Estrace may also cause other side effects. Call your doctor if you need information about them.