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Prescribing Information for Cymbalta (Duloxetine):
What is Cymbalta?
Cymbalta belongs to the group of antidepressants called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It acts by affecting certain chemicals in the brain that may provoke depression if they are not balanced.
Cymbalta is commonly prescribed for treatment of major depressive disorder and general anxiety disorder.
It can be also prescribed for other purposes.
What is important to know about Cymbalta?
Cymbalta should not be used together with thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). Wait at least two weeks after stopping an MAOI before you start Cymbalta. Do not stop using MAOI earlier than 5 days after your last dose of Cymbalta.
Taking antidepressants for the first time can cause suicidal thoughts especially among people under 24. You will need to be examined by your doctor regularly for the first 12 weeks of treatment or more.
Call your healthcare provider immediately if you experience any new or aggravating symptoms like: changes of mood or behavior, panics, anxiety, insomnia, irritability, impulsiveness, hostility, aggression, agitation, if you feel mentally or physically hyperactive, more depressed or restless or if you have thoughts of self-injury or suicide. Do not drink alcohol while using Cymbalta. It may make the risk of damaging your liver higher.
Cold or allergy medications, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety can add to sleepiness caused by Cymbalta. Inform your doctor if you use any of these medications.
Cymbalta can affect the way you think or react. Be careful if you drive or do any other activity requiring attention.
How should Cymbalta be used?
Follow the prescriptions of your doctor and the instructions which come with the medication carefully. Do not change your dose and do not use Cymbalta for a longer period than prescribed. Your doctor may adjust your dose to make certain that you get the most benefit from treatment.
It is recommended to take Cymbalta at the same time every day. You should follow the instructions on the prescription label.
Swallow the Claritin sustained-action capsule whole without crushing, chewing, or breaking it to prevent releasing of too much medicine at once. You may need at least 4 weeks to feel better. To get the most benefit, continue taking the medication as prescribed. You should not stop taking the medication suddenly without your doctor’s advice to prevent having undesirable side effects. Keep Cymbalta at room temperature protected from moisture and heat.
What side effects can Cymbalta cause?
Seek emergency medical attention if you experience an allergic reaction to Cymbalta (trouble breathing; hives; swelling of your face, lips, tongue, or throat).
Call your healthcare provider immediately if you experience any new or aggravating symptoms like: changes of mood or behavior, panics, anxiety, insomnia, irritability, impulsiveness, hostility, aggression, agitation, if you feel mentally or physically hyperactive, more depressed or restless or if you have thoughts of self-injury or suicide.Call your doctor promptly if you develop any of the following serious conditions:
- headache, trouble concentrating, memory problems, confusion, hallucinations;
- weakness, feeling unsteady, loss of coordination, fainting, seizure, shallow breathing or breathing that stops;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- easy bruising or bleeding, nosebleeds;
- very stiff (rigid) muscles, high fever, vomiting, diarrhea, sweating, fast or uneven heartbeats, tremors, overactive reflexes;
- black, bloody, or tarry stools; or
- painful or difficult urination.
- weight changes;
- joint or muscle pain;
- drowsiness, dizziness, spinning sensation;
- mild nausea, constipation, gas;
- decreased sex drive, impotence, or difficulty having an orgasm;
- sleep problems (insomnia); or
- dry mouth, blurred vision.
Cymbalta may also cause other side effects. Talk with your doctor if you need medical advice about them.