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Prescribing Information for Cozaar (Losartan):
What is Cozaar (Losartan)?
Cozaar is the drug main by used to treat high blood pressure. It contains losartan potassium as an active ingredient. Cozaar is being manufactured by Merck Sharpe & Dohme.
Cozaar (Losartan) belongs to angiotensin II antagonist category of drugs. Losartan potassium is the main ingredient of Cozaar. It acts on the body by inhibiting a hormone known as angiotensin II.
Angiotensin II is a hormone which acts on the blood vessels and constricts them. It acts by two basic mechanisms. Firstly, it narrows the peripheral blood vessels and secondly, it stimulates one nose hormone occurring naturally in the body known as aldosterone. Latter is known to cause retention of salts and water in body by acting through the kidneys. It increases the volume of fluid in the blood vessels. As a result of it, the blood pressure in body increases.
Cozaar (Losartan) has been used by many physicians around the globe to treat the high blood pressure and many people have proved Cozaar all over the world.
This drug is really safe and has been proved clinically as well as through experiments. Angiotensin II inhibitor acts by inhibiting the angiotensin II and by preventing its action. It stops the action of angiotensin II on peripheral blood vessels which are allowed to relax. Thus, a less resistance is produced in the blood vessels. This is the first mechanism by which losartan potassium or Cozaar acts in the body. If angiotensin II will be stopped, aldosterone will not be produced anymore. The kidney will not retain salt and water further and the blood vessels not contain excess amount of fluid. Therefore, there will be lesser peripheral resistance and hence, lesser blood pressure on the blood vessels in the body. This combined effect lowers the blood pressure and hence, Cozaar treats the high blood pressure or hypertension state.
Cozaar (Losartan) has also been used to treat severally high blood pressure. It will also reduce the risk of stroke in patients who are proving to have myocardial infarction.
People with excessive heart size or enlarged heart with LVH or left ventricular hypertrophy are also helped by this drug.
The drug should not be prescribed for treatment of stroke but to prevent the occurrence. There are separate drugs for treatment of stroke and LVH. Cozaar is preventive for occurrence of stroke and myocardial infarction.
Basic indications of Cozaar are high blood pressure or mild to moderate hypertension. Delaying the progress of any renal disease and it is also useful for DM Type 2 patients. People with renal complications can also use Cozaar like diabetic neuropathy and microalbuminuria.
What should I know about Cozaar (Losartan)?
Before you start using Cozaar, there are some conditions that you must know. Cozaar can produce dizziness and fatigue occasionally. You should not take this drug with alcohol. The amount of sedation can increase with alcohol and other sedative drugs.
Do not combine Cozaar with any other drug which is as well known to treat blood pressure.
You should not work on heavy machines or drive heavy vehicles after taking Cozaar as it may produce varying amount of drowsiness.
You must conduct blood tests regularly so that you can monitor the blood potassium levels. Cozaar (Losartan) can also cause increased amount of potassium in blood.
This drug should be used carefully in patients over 75 years of age. The clinical proving are not sufficient in older people.
Cozaar (Losartan) can produce severe side effects in patients with liver dysfunction.
Do not use it by people suffering from severe cardiac troubles.
Use it cautiously in patients who had a history of swelling of lips, face and tongue or angiodema and in people with aortic and mitral valve stenosis.
Doesn’t use the drug in case the patient is having narrowing of main arteries of body and those who had a recent kidney transplant can use it only after a prescription from their physician.
You must take cautious while using this drug in persons with moderate to severe renal diseases and liver disorders.
This drug should not be used in pregnancy and breastfeeding.
You should not be allergic to any components of Cozaar before taking it. You can ask your doctor for an allergic test. If you have used any drug of this category and have experienced allergy or severe side effects do not take this drug until your doctor prescribes it.
How should I take Cozaar (Losartan)?
There is a great amount of information that you must know before taking Cozaar. You must try to take the medication exactly it has been prescribed by your doctor. Do not over dose the medicine.
Avoid taking it for a longer duration than prescribed by your physician.
Carefully read the instructions on the prescription label.
You cannot combine alcohol and Cozaar (Losartan).
Avoid potassium supplements and drugs which increase the blood potassium levels.
If you mild any dose of Cozaar, take it immediately as you get reminded of it. But do not overmedicate yourself as you can have severe side effect. If any overdosing occurs contact your medical service provider immediately.
Cozaar (Losartan) will begin to act in 4 to 6 weeks before your blood pressure is controlled.
To get good results use Cozaar as directed by your doctor. You must talk to your doctor if no improvement is seen. In case of severe side effects, take medical advice immediately.
Usually it is taken without food.
Your doctor can change the dose amounts to get best results in you. You cannot alter the amount of dose as given by your doctor and store Cozaar away from excessive moisture and light.
What are the possible side effects of Cozaar (Losartan)?
There are different side effects that Cozaar may produce in various ways in every individual. Some of the side effects are common, uncommon and some are very rare side effects of Cozaar before taking it. Take to your physician so that he can tell you more about the side effects of Cozaar.The common side effects are:
- loss of strength,
- high potassium levels and diarrhea.
- moderate hypertension,
- anemia or low RBC count.
You may feel light headed. Severe side effects occur rarely. These can be found in patients allergic to this category of drugs. The severe side effects are hepatitis or inflamed liver, migraine, cough, rashes on skin with itch, pain in muscles or myalgia, arthralgia and angiodema i.e. swelling of lips, face or tongue.
Side effects may not occur at all or vary from individual to individual.
Do not take in pregnancy and breastfeeding as it can harm the developing fetus and newborn infant.
How Cozaar (Losartan) interacts with other drugs?
Cozaar may affect other medicines and can become less or more effective. Do tell your doctor about all herbal drugs or supplements you have been taking your doctor will let you know about the medicines contraindicated with Cozaar. It can increase the blood potassium supplement, potassium sparing diuretic like spironolactone and potassium containing salt substitutes.
Do not take Cozaar with non-steroidal anti-inflammatory drugs like ibuprofen, diclofenac etc. Do not take Cozaar with furosemide and other diuretic drugs. Your doctor will reduce the dose of Cozaar when taken with diuretics. It increases the blood lithium levels too. Contact your doctor if you feel sudden side effects and stop taking this drug.