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Prescribing Information for Bactrim (Trimethoprim):
What is Bactrim (Trimethoprim)?
Bactrim (Trimethoprim) contains trimethoprim and sulphomethoxazole as an active ingredient. Bactrim is a drug mainly used for the treatment of bacterial infections. Bacteria contains two main compounds-trimethoprim and sulphomethoxazole. These two belongs to the sulfonamide group of the antibiotic. Both the compounds are known to act on the bacterial cells. They can stop the manufacture of folic acid in the bacterial cells.
What should I know about Bactrim (Trimethoprim)?
Folic acid is necessary for the synthesis of DNA in bacteria. DNA is not manufactured bacteria can’t replicate. Hence, bacteria are killed indirectly by making them deficient of folate. This is also known as bacteriostatic effect of the drug where the infection is reduced by stopping the bacteria to grow.
How to use Bactrim (Trimethoprim)?
Bactrim (Trimethoprim) is mainly used in chronic bronchitis, infection of bladder or urinary tract infection (VTI), ear infections like otitis media. It is also used for the prevention of pneumonia caused by bacterium pneumocytis carinii. It can even treat the pneumonia caused by the same bacterium.
To avoid the side effects of Bactrim (Trimethoprim), you must consume plenty of liquids along with it. You should go for regular blood test to know the critical blood values use bacterium carefully in patients having blood disorders, low kidney and hepatic function, in old people in infants order 6 weeks of age and in G-6-P-D disease and in asthmatic disorders.
Bactrim (Trimethoprim) is contraindicated in patients in liver failure, and rare blood disorder known as porphyrias. This drug should not be used during pregnancy as the developing fetus may get malformations and developing disorders in the growing baby. Bactrim can pass through mother’s milk; hence, you should not use it while breastfeeding your child you must take the drug as prescribed by your doctor and for the time duration given on your prescription label.
What are the possible side effects of Bactrim (Trimethoprim)?
Bacterium may cause some side effects which are common to the drug. It may rare side effects in very few people depending upon their susceptibility and other factors. Common side effects are headache, rashes, diarrhea, constipation, vomiting and nausea. Moderate to severe side effects include blood diseases, convulsions or seizures, Stevens Johnson syndrome, inflammation of month lining or stomatitis, liver failure, pain in muscles or myalgia and renal damage.
How Bactrim (Trimethoprim) interacts with other drugs?
Bactrim (Trimethoprim) can cause renal failure if it is taken along with ciclosporin. It can cause heart rhythm disease, when used along with amiodarone. Bactrim can increase the INR or blood clotting time when stacked with warfarin. It can cause low blood sugar in the plasma with sulphonylureas. It can reduce the effectivity of oral contraceptive medicines. Bactrim (Trimethoprim) when taken along with Methotrexate will increase the toxic side effects. This should not combine with phenytoin or the levels of folic acid may decrease in the body and produce deficiency symptoms. Take Bactrim with water only and do not take it along with alcohol. Keep the drug away from moisture and heat.