iSmithers Rapra Publishing has announced the release of Update on Polymers for Ocular Drug Delivery.
The eye is the most easily accessible site for topical administration of a medication. Drugs are commonly applied to the eye for localised action on the surface or in the interior of the eye. A major problem in ocular therapeutics is the attainment of an optimal drug concentration at the site of action. Poor bioavailability of drugs from ocular dosage forms is mainly due to the precorneal loss factors which include tear dynamics, non-productive absorption, transient residence time in the cul-de-sac, and the relative impermeability of the corneal epithelial membrane. Due to these physiological and anatomical constraints only a small fraction of the drug, effectively 1% or even less of the instilled dose is ocularly absorbed.
The effective dose of medication administered ophthalmically may be altered by increasing the retention time of medication in contact with the surface of the eye. To date, Pharmaceutical Technologists have tried to develop different novel formulations like gel, ocular inserts, collagen shields, implants, liposomes, nanoparticles, penetration enhancers and in-situ gelling systems, in order to increase the bioavailability and duration of the therapeutic action of ocular drugs and polymers plays an important role in all these approaches.
This book provides detailed information regarding all such polymers which have been used and shown to be excellent in improving the bioavailability of ocular drugs.
Update on Polymers for Ocular Drug Delivery is available from retailers, at www.polymer-books.com
Read a Sample Chapter and view the Table of Contents.
About Smithers Rapra:
Smithers Rapra is a wholly owned subsidiary of The Smithers Group and is recognised as a World leading rubber, plastic and composite consultancy. Smithers Rapra provides a comprehensive independent service covering, testing, analysis, processing and research for the polymer industry and industries using plastic, rubber and composites in any component, product or production process. www.rapra.net
iSmithers evolved from the information division of Smithers Rapra in 2008 after delivering over 30 years of knowledge transfer solutions. It serves a global academic and industrial market with polymer, chemical, pharmaceutical, ecotoxicology and life-science related knowledge and information products and events. These include a wide range of technology and market-based journals and books, national and international conferences, polymer technology training courses and electronic web and database products. www.ismithers.net