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20 Feb 2012 03:08 PM

Macrobid - Effective Antibiotic for Urinary Tract Infection


Nitrofurantoin is an antibiotic that is sold under many brand names depending upon the region and pharmaceutical company manufacturing it. Macrobid is one such brand under which the generic nitrofurantoin is sold for treating urinary tract infection. This is a gelatin capsule which has 100 mg of active ingredient in two forms. 75 mg is nitrofurantoin monohydrate and 25 mg are macro crystals of the same.
It is necessary to take this medicine only with a checkup with your physician and with a valid prescription. Macrobid is specifically active against specify types of bacteria and therefore to avoid developing drug resistant bacteria and to obtain complete efficacy of this drug it is recommended to use it for proven ailments for which it has been developed. Unlike few other antibiotics this one has significance as its use in pregnant women does not pose threat to them or the baby up to certain amount.
Macrobid is effective against E.coli and Staphylococcus species. The mechanism of this agent is unique and is supposed to attack the bacterial DNA in its bactericidal activity. Once the active ingredient nitrofurantoin gets inside the bacterial cell it gets reduced to a highly reactive complex that attacks the ribosomes and other molecules inside the bacterial cell which proves fatal for it.
As this drug is not a broad spectrum antibiotic it is indicated to use it only in conditions of urinary tract infection where the causing bacterial species is E.coli or Staphylococcus saprophyticus. The dosing of this medicine is one capsule of 100 mg in 12 hours.
Some of the common side effects with the use of this drug are nausea, headache and gas. Other symptoms include flatulence in the abdominal region along with a minor pain. Few patients also reported dizziness, drowsiness, fever, chills etc.
Before you start taking Macrobid [nitrofurantoin] it’s important for you to discuss your medical history in detail with your physician. Tell the pharmacist or your doctor if you are allergic to this drug or its inactive ingredients. It may happen that you may be allergic to one of the inactive substance used in combination to make this medicine. Taking this without complete knowledge of the ingredients may prove harmful and lead to allergic reaction thus increasing more complications and threat to your body. Also there are certain medical conditions in which this drug is contraindicated. If you have weak immune or kidneys then it is best to consult your doctor. A genetic condition in which there is a deficiency of G-6-PD or liver diseases must not use this medicine.
An important note of taking any antibiotic drugs is the completion of its course. It may happen after few days of treatment with antibiotics the patient may feel completely cured and may tend to stop the antibiotic dose/course in between. This is a wrong practice and antibiotic prescribed must be taken for the complete duration as mentioned in the course to avoid antibiotic resistant strain. Taking complete course is a fundamental step while on any antibiotic therapy.
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