Estrogens are amongst very crucial female hormones that play a significant role in a women’s life. Estrogen and its derivatives are used in various forms such as tablets, creams solutions to maintain and regulate female’s biological activities such as birth control, menstrual cycle, menopause etc. Estrogens primarily are converted to two basic forms when a woman is in her active menstrual cycle age. Daily approximately the ovaries produce 70 to 500ug of estradiol
which eventually gets converted to estrone and estriol. Development of sex organs and hair around the pubic region are all result of estradiol and its byproducts. Women tend to have an additional advantage over men as estrogens also help in keeping the bad cholesterol level in check. It promotes the HDL cholesterol concentration in the circulatory system. The uterine and the muscles of the cervix along with the secretions are all managed with the optimal release of Estradiol hormone in the female body. As women age increases estrogen and other hormones may be administered from outside sources which helps to prevent hip fracture and osteoporosis symptoms after menopause hits in them. Estrace
is the brand under which estradiol can be obtained from the pharmacist. Available are the micronized tablets of strength 0.5mg, 1mg and 2mg. there are vaginal creams that can be directly applied on the interior walls of cervix and vagina. Some women prefer to put a patch on their skin which is continuousrelease hormone and its requirement is adjusted to 14 mcg/0.05mg/1mg everyday depending upon the body’s need.
The best storing temperature to keep all forms of Estrace products is between the ranges of 15C to 30C.
Estrace [Estradiol] is basically prescribed for the menopause related symptoms such as vaginal dryness, mood swings, hot flashes, etc. Other significant ailments where it can be given are heavy uterine bleeding, prevention of hip fracture due to osteoporosis and reducing the risk of heart attacks to some extent. In most of these cases an oral drug is a conventional choice but in cases of vaginal or vulvar atrophy Estrace cream provides quick results and relief.
Dosing of Estradiol tablets can be taken in a regular cyclic regime. Mostly prescribed once a day these medicines must be administered for 23 days in a sequential manner. Thereafter 5 days no medication and then the cycle resumes. The hormonal patch must be used on a clear hairless skin and away from the breast. It must not be used on a damaged or open wound with irritated skin. Only one site of application must be avoided and must be rotated periodically. Once the protective layer of the patch is taken off, it must be immediately applied with an approx. 10 to 15 seconds of pressure so that it attaches firmly to the skin surface. Women who take estradiol must consult with their gynecologist if they are experiencing any side effects such as irregular menstrual cycle or other severe symptoms such as seizures, nausea, excessive weight gain etc. Those with liver disease and ongoing treatment such as warfarin
must take precaution while taking Estrace [estradiol] as it increases the risk of clotting factors and reducing the ability of other drugs.