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14 Feb 2012 02:12 PM

Fexofenadine – Antihistamine pharmaceutical drug


Brand name – Allegra, Allegra Hives, Children’s Allegra, Allegra Allergy

Generic name – Fexofenadine

Fexofenadine is ‘second generation’ oral antihistamine which is used in treating symptoms and signs of hives and allergy. Fexofenadine (Allegra) is similar to certizine (Zyrtes), loratadine (Claritin) and azelastine (Astelin) second generation antihistamines. Histamine is the chemical which is responsible for most of symptoms and signs of allergic reactions like sneezing, itchy eyes and swelling of lining of nose. Histamine storing cells releases histamine and then it attaches to some other cells which have receptors for the histamine. Cells activation and releasing some other chemicals which produce effects which we associate with allergy is caused by attachment of histamine to receptors.
Fexofenadine (Allegra) blocks the H1 receptor and prevents activation of the H1 receptor by histamine. Fexofenadine (Allegra) cause less drowsiness because it does not readily brain from blood. Fexofenadine (Allegra) and second generation anti histamines are called as non sedating antihistamines. .In July 1995 Food and Drug Association approved Fexofenadine (Allegra). Fexofenadine (Allegra) is used in treating symptoms of allergies in children and adults. Fexofenadine (Allegra) is also used in treating hives and skin itches caused by condition which is known as chronic idiopathic urticaria in children and adults.
Fexofenadine (Allegra) is available in 30mg, 60mg, and 90mg tablets. Fexofenadine (Allegra) suspension is available as 30mg/5ml. For treating urticaria and seasonal allergies recommended dose for children of twelve years age or older and adults is 60mg two times per day or 180mg onetime per day. 2-11 years old children should be given thirty mg two times per day for urticaria and seasonal allergies. Six months to two years old children should be given15 mg two times per day for urticaria. For children who are less than six years old Fexofenadine suspension is used.
The effect of Fexofenadine (Allegra) in pregnancy and nursing mother has not been studied adequately. Aluminium or magnesium containing antacids reduce absorption of Fexofenadine. Aluminium containing antacids like Moalox reduce absorption of Fexofenadine if it is administered fifteen minutes apart. Therefore Fexofenadine and aluminium containing antacids should not be taken together. Apple juice, orange juice or grape fruit juice may reduce absorption of Fexofenadine (Allegra). It should be taken with water only. St. John’s Wort and its preparations interact with Fexofenadine. If you have medical history of kidney disease, tell your doctor before starting Fexofenadine treatment. Kidney removes this medication. Rapidly dissolving tablet can contain aspartame. If you have a condition which requires restriction for aspartame intake or you have phenylketonuria, consult with your doctor about using this medicine safely.
Fever, cough, stuffy nose, stomach upset, back pain, menstrual cramps, earache, dizziness, headache, diarrhea, nausea, vomiting, weakness, muscle aches and allergic reactions are some side effects of Fexofenadine (Allegra) treatment. This treatment does not cause drowsiness generally when used under normal circumstances and at recommended doses. Many people using Fexofenadine treatment do not have major side effects. If major allergic reaction like itching or swelling (especially of tongue, throat or face), rash, trouble breathing and severe dizziness occurs seek immediate medical help.
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