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03 Feb 2012 09:35 AM

CITALOPRAM (CELEXA)- AN ANTIDEPRESSANT


Citalopram - Brand names are Cipramil, Celexa. Citalopram (Celexa) is antidepressant medication. This affects neurotransmitters. Nerves manufacture and release neurotransmitters and after that neurotransmitters travels and attaches to nearby nerves. So neurotransmitters can be said as brain’s communication system. It is believed that depression is caused due to imbalance of neurotransmitters. Citalopram (Celexa) affects the chemicals which are in brain and may become unbalance causing depression. Citalopram is used to treat depression. Citalopram is in selective serotonin reuptake inhibitors class of drugs. This class also includes paroxetine, fluoxetine and sertaline. In July 1998 FDA approved Citalopram.
Citalopram (Celexa) is used in depression management. It is used in treatment of obsessive compulsive disorder, premenstrual dysphoric syndrome, posttraumatic stress disorder and anxiety disorder. Generally the dose of Citalopram (Celexa) starts with twenty mg in morning or in evening. You can take it with food or without food. There is no increase in absorption of Citalopram when it is taken with the food. The dose can be increased up to forty mg after one week. Dose of sixty mg is not found more effective than dose of forty mg. Like other antidepressants Citalopram (Celexa) may take many weeks to show the maximum effects. To find exact effective dose, doses are adjusted upwards slowly. In therapeutic dose range Citalopram is considered well tolerated and safe.
All selective serotonin reuptake inhibitors including Citalopram (Celexa) are not supposed to take with the mono-amine oxidase inhibitor type of antidepressants, such as procarbazine, selegiline, phenelzine, tranylcypromine and isocarboxazid. These combinations may lead to high blood pressure, hyper activity, tremor and confusion. Use of Citalopram (Celexa) with nonsteroidal anti-inflammatory drugs and aspirin may increase likelihood of gastrointestinal bleeding. Tryptophan, a dietary supplement if taken with Citalopram may cause dizziness, sweating, headaches and nausea. Adverse effects can be caused in the infant of mother getting treated by Citalopram. The suicidal thinking risk is increased due to antidepressants. Patients on treatment of Citalopram (Celexa) must be observed very closely for unusual changes in behavior, suicidality and clinical worsening.
An often side effect with Citalopram (Celexa) is sexual dysfunction. To specify, these effects include lack of interest in sex, genital anesthesia, difficulty becoming aroused and decreased response to sexual stimuli. These effects are usually reversible. But sometimes after complete withdrawal of Citalopram (Celexa) also these effects can be seen for many months or years. Some side effects of treatment are common such as decreased sex drive, dry mouth, trembling, increased sweating, fatigue, excessive yawning, diarrhea, anorgasmia, weight changes, nausea, vivid dreaming, drowsiness, insomnia and frequent urination. Bruxism, dilated pupils, blood pressure changes, mood swings, anxiety and headache are some side effects of Citalopram (Celexa) which are less common. Convulsions, severe allergic reactions and hallucinations are side effects of Citalopram which are very rare. The dose can be taken at night rather than morning if sedation occurs. Overdose of Citalopram (Celexa) may result in sedation, vomiting, dizziness, disturbances in heart rhythm, nausea, sweating, tremor, coma, confusion or convulsions. Many deaths have occurred due to the over dose of Citalopram.
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