Estrogens-Commercial name is Premarin
. The name is isolated from Pregnant Mares Urine. Wyeth Pharmaceuticals are the manufacturers of Premarin (Estrogens) and marketing it since 1942. Estrogens and Progestins are two major types of female hormones. Premarin (Estrogens) are used for treating the menopause symptoms. It is available in oral, topical and IV form. Estrone more than fifty percent, equilenin, and equilin up to fifteen to twenty five percent are main forms of Estrogen in Premarin (Estrogens.) The Estrogens which are present in Premarin are usually called as ‘conjugated equine estrogens’. In Premarin (Estrogens) the major active constituent is estrone sulphate.
After taking a Premarin (Estrogens) tablet by women the estrone sulphate is very easily absorbed in the blood. Estrone sulphate converts into the estradiol which is active estrogen usually found in women. Whether the effects of Estrogens like equilin which are foreign to human body are different or not from the effects of estrogens such as estradiol which are usually made in human body is not cleared yet. Development and growth of female sexual organs, growth of pubic hair and underarm is caused due to Estrogens (Premarin). Estrogens (Premarin) raise secretions from cervix, and also increase growth of inner lining of uterus.
Tablets of Premarin (Estrogens) are available in 0.3mg, 0.45mg, 0.625mg, 0.9mg and 12.5mg. The vaginal cream of Premarin (Estrogens) is available in preparation of 0.625mg/gm of cream. The Premarin tablets and cream are supposed to store at room temperature. The injection is stored between 2 degree centigrade and 8 degree centigrade. Premarin (Estrogens) are used in treatment of menopause symptoms which includes vaginal dryness, hot flashes and vaginal atrophy. When body is not able to produce sufficient Estrogens due to removal of ovaries (castration), or when ovarian failure occurs, and in case of hypogonadism Estrogens (Premarin) is used as therapy. They may be beneficial for treatment of breast cancer and advanced prostate. Premarin (Estrogens) are approved for osteoporosis prevention, but some other drugs are usually used for this purpose. When abnormal uterine bleeding occurs because of hormonal imbalance intravenous Estrogens are used to treat this.
The ability of liver to manufacture factors which promote clotting of blood is increase by Estrogens (Premarin). Due to this patients with warfarin which is a drug that thins blood needed to be observed when started with Estrogens. Use of medications like Rifampin
, Carbamazepine, barbiturates, phenytoin, griseofulrin and St John’s wort with Estrogens (Premarin) may cause reduction in useful effects of Estrogens. Pregnant women
are not supposed to give Estrogens treatment. Breast feeding women should not take Estrogens as it may cause side effects in infant. Abdominal pain, headache, nausea, joint pain, back pain, nervousness and vaginal bleeding are some common side effects of Premarin (Estrogens). Patients may experience loss of periods, excessive prolonged periods, vaginal spotting, breast pain and increase/decrease in sexual drive. Blood clots in lungs or legs occur sometimes in women with Estrogens (Premarin). The side effects on skin include melasma on cheeks and forehead, rash and they may persist after withdrawal of Estrogens (Premarin).