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02 Feb 2012 09:10 AM

What is Esomeprazole


Esomeprazole, brand name is Nexium and is marketed and developed by AstraZeneca. Esomeprazole (Nexium) is one type of drugs called as proton pump inhibitors. They are used in blocking the production of acids by stomach. They decrease the acid production amount in stomach. Omeprazole, lansoprazole, rabeprazole and pantoprazole are some other drugs which are also included in same class or type of medicines. Esomeprazole (Nexium) is closer or similar to Omeprazole. For treating conditions like stomach ulcers and duodenal ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease which are due to stomach acid proton pump inhibitors (Esomeprazole) are used.
Like other proton pump inhibitors Esomeprazole (Nexium) is used to block the enzyme in wall of stomach which produces acid. The decrease in production of acid is done by blocking enzyme. Esophagus and stomach are allowed to heal by this. In Feb 2001 FDA approved Esomeprazole. Esomeprazole (Nexium) is prescribed for gastroesophageal reflux disease treatment, for treatment of ulcers and H-pylori infection in combination with clarthromycin and amoxicillin. It is used in treatment for reduction in gastric ulcers risk which is associated with NSAID. For promoting the healing of the erosive esophagitis Esomeprazole (Nexium) are used.
Esomeprazole (Nexium) capsules should be taken one hour before meal. Capsules are designed for swallowing whole and they are not supposed to crush or chew. Patients who have problem in swallowing the capsule, they can open it and can mix pellets of capsule with applesauce. Applesauce should be at room temperature and pellets are not supposed to crush and chew. The dose of Esomeprazole (Nexium) for gastroesophageal reflux disease is twenty to forty mg Esomeprazole one capsule daily for four to eight weeks. For the age of one to eleven the course varies from ten to twenty mg daily. For the patients of H-pylori the dose is forty mg once in a day with clarthromycin and amoxicillin combination for ten days. For prevention of NSAID-induced ulcers the dose is twenty to forty mg daily, continued for six months. Forty mg capsules two times in a day are given for Zollinger-Ellison syndrome.
The person who is allergic to Esomeprazole should not use it. If you are allergic to medications of benzimidazole like mebendazole or albendazole don’t use Esomeprazole (Nexium). Before starting course of Esomeprazole (Nexium) meet your doctor if you are a patient of any liver disease and any heart disease. It is advised that in breast feeding don’t take these medicines. Sucrose is present in these capsules. So it is not advisable for the persons having problems of sucrose isomaltase insufficiency and fructose intolerance. If you feel any allergic signs like difficulty in breathing or hives or face swelling, lips swelling, tongue swelling, get immediate medical treatment. Constipation, gas, stomach pain, headache, diarrhea or dry mouths are some side effects caused by Esomeprazole. Some uncommon side effects are spinning sensation, sleepiness, increased liver enzymes, swelling of legs and ankles, par aesthesia and some skin reactions. Stating these side effects does not mean that every person will experience these side effects who are taking the Esomeprazole (Nexium) course.
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