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01 Feb 2012 08:34 AM


Orlistat is marketed with the trade name of Xenical which is manufactured by Roche in many countries or with the trade name Ali, manufactured by GlaxoSmithKline in United States and United Kingdom. Orlistat is one type of medicine which is called as a lipase inhibitor. Orlistat is an active ingredient in Xenical capsules. It is designed for treating obesity with certain factors like high blood pressure, triglycerides, high cholesterol and diabetes. In water it is practically insoluble. In chloroform Orlistat is freely soluble whereas in methanol and ethanol it is very soluble. In weight loss the effectivity of Orlistat is definite. The clinical trial suggests that the people using Orlistat with addition to their exercise and diet lose 2-3kgs more than the people not talking Orlistat.
Orlistat (Xenical) works locally in small intestine and stomach. In stomach two compounds are found in digestive juices. Gastric lipases and pancreatic lipases are these compounds. Usually these compounds break down the fats we consume from our diet. The fat from our diet is made from molecules which are very large to absorb from gut into bloodstream. In process of digestion these large molecules need to break down in small molecules to get absorb in the bloodstream. This function is carried out by gastric lipases and pancreatic lipases. Orlistat prevents these compounds work. It prevents the fat from breaking down and absorbing by the body. That means a body is unable to use fat as energy source or is unable to convert the fat into the fat tissues.
The dose for Xenical (Orlistat) capsules is three capsules per day during the meals or before one hour after your meals. Due to Orlistat fats are excreted in faeces. It helps in losing weight. The Xenical capsule should be taken during a meal which contains up to 30% fats. If you are skipping your meal or you are not taking a meal which is not having some fats in it, then skip your Xenical (Orlistat) dose for that time. Fat content of daily meal should be up to 30%, but not greater than that. You must avoid a high fat diet. High fat diet in combination with Xenical (Orlistat) capsule will increase some side effects on intestine or stomach.
Xenical capsules should not be taken by the people who are allergic for Orlistat, or who are unable in absorbing nutrients and food properly, or who have any gallbladder problem. It is contraindicated in breastfeeding and pregnancy. After starting the course of Xenical (Orlistat) capsules if you suffer from any signs of allergic reactions like swelling of your tongue, throat, face or lips, hives or difficulty in taking breath then immediately contact with your doctors. Some commonly occurred side effects with use of Xenical (Orlistat) are oily spots in undergarments, fatty or oily stools, brown or orange colored oil in stool, increase in bowel movements, gas with oily discharge, vomiting, nausea, weakness, and some others. Usually all side effects are temporary, as you continue with the Orlistat they may lessen.
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