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27 Jan 2012 07:02 AM

10 Interesting Facts about Anti Depressant Bupropion


Also sold under different brands name like Wellbutrin, Wellbutrin SR, Wellbutrin XL, Voxra, Zyban, Aplenzin or Budeprion, Bupropion comes under the class of medications called anti depressants. Bupropion is used to treat several depressive disorders like bipolar disorder, manic depressive disorder, and attention deficit hyperactivity disorder (ADHD) etc. It is also used to cure Seasonal Affective Disorder SAD. Along with that, it’s also widely accepted as a strong smoking deterrent. .
According to research done in 2007, Bupropion is the fourth most frequently prescribed drug among the 20 million retail prescriptions in the US. One of its brands called Zyban is popularly used as a smoking cessation medicine as it helps in reducing withdrawal effects and cravings. Best for relieving mental depression, Bupropion comes in tablet form to be taken orally and the dose varies according to the condition and requirement of the patient. Below are some important and interesting facts about Bupropion:

1)Bupropion was initially revealed in the US by Burroughs Research in 1966. It comes under the drug class of Amino Ketone anti depressants, Dopamine Reuptake Inhibitor and Norepinephrine.

2)In general, the structure of Bupropion is very much similar to phenethylamines and stimulant cathinone. It is chemically evolved from diethylopropion which is an amphetamine-like element and used as an anorectic.

3)Bupropion is chemically unassociated with tricyclic or tetracyclic agents.

4)Bupropion was approved by FDA in December 30th, 1985 for IR formulation, October 4th, 1996 for SR formulation and August 29th, 2003 for XL formulation.

5)Wellbutrin XL approved in 2003, is the most recent formulation and is taken only once a day. It is good for treating Seasonal Affective Disorder which occurs in fall and winter season each year. Compared to other anti depressants, Wellbutrin has very low chances of causing seizures.

6)In the year 2000, Bupropion was certified as a pharmacotherapy for smoking cessation while in 2006 it was licensed for treating episodes of Seasonal Affective Disorder in the United States.

7)Some countries have not approved this medicine for treating depression; they have only authorized it as a smoking cessation drug.

8)Depressed patients, who are not reacting to SSRIs, are usually switched to Bupropion.

9)Clinical studies have shown that Bupropion lowers weight and depressive symptoms in overweight adults.

10)Bupropion does not usually affect the libido, has very low risk of triggering manias and less chances of causing nausea, somnolence and diarrhea as compared to SSRIs.

The anti depressant Bupropion may also cause minor side effects like dry mouth, vomiting, dizziness, excitement, headache, weight loss, uncontrollable shaking of some body part, headache and constipation. There’re some serious side effects listed in the “important warning” section, for which it is necessary to consult the doctor as soon as possible; these include: seizures, swelling of different parts of the body, chest pain, irregular heartbeat, hallucinations, fever and difficulty in swallowing or breathing.
It is highly recommended that you store Bupropion in a cool and dry place away from moisture, in a tight container. Make sure it is far away from your children’s reach. Pregnant women must consult a doctor before using it as it might cause severe side effects. Never keep outdated Bupropion and ask from your doctor how to dispose it of properly.
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